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norskBlar i forfatter "Llor, Carl"
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Antibiotic prescribing for acute Respiratory tract infections 12 months after communication and CRP training: a randomized trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03)<i>PURPOSE</i> - C-reactive-protein (CRP) is useful for diagnosis of lower respiratory tract infections (RTIs). A large international trial documented that Internet-based training in CRP point-of-care testing, in enhanced communication skills, or both reduced antibiotic prescribing at 3 months, with risk ratios (RRs) of 0.68, 0.53, 0.38, respectively. We report the longer-term impact in this ... -
Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: Secondary analysis of a randomised controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)<i>Background</i> - C-reactive protein (CRP) point-of-care testing can reduce antibiotic use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in primary care, without compromising patient care. Further safe reductions may be possible.<br><br> <i>Aim</i> - To investigate the associations between presenting features and antibiotic prescribing in patients with ... -
Associations with Post-Consultation Health-Status in Primary Care Managed Acute Exacerbation of COPD
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-16)Background: It has been demonstrated that antibiotic prescribing for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) can be safely reduced in primary care when general practitioners have access to C-reactive protein (CRP) rapid testing.<p> <p>Aim: To investigate the factors associated with post-consultation COPD health status in patients presenting with AECOPD in this sett ... -
C-reactive protein point-of-care testing and complementary strategies to improve antibiotic stewardship in children with acute respiratory infections in primary care
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)This paper provides the perspective of an international group of experts on the role of C-reactive protein (CRP) point-of-care testing (POCT) and complementary strategies such as enhanced communication skills training and delayed prescribing to improve antibiotic stewardship in the primary care of children presenting with an acute illness episode due to an acute respiratory tract infection (ARTI). ... -
C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: The PACE RCT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03)Background - Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed antibiotics, but these may not be beneficial, and they can cause side effects and increase the risk of subsequent resistant infections. Point-of-care tests (POCTs) could safely reduce inappropriate antibiotic prescribing and antimicrobial resistance.<p> ... -
C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-11)<i>BACKGROUND</i> - Point-of-care testing of C-reactive protein (CRP) may be a way to reduce unnecessary use of antibiotics without harming patients who have acute exacerbations of chronic obstructive pulmonary disease (COPD).<p><p> <i>METHODS</i> - We performed a multicenter, open-label, randomized, controlled trial involving patients with a diagnosis of COPD in their primary care clinical ... -
C-reactive protein-guided antibiotic prescribing for COPD exacerbations: A qualitative evaluation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-25)Background - Antibiotics are prescribed to >70% of patients presenting in primary care with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The PACE randomised controlled trial found that a C-reactive protein point-of-care test (CRP-POCT) management strategy for AECOPD in primary care resulted in a 20% reduction in patient-reported antibiotic consumption over 4 weeks.<p> <p>Aim ... -
General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): Study protocol for a randomised controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-29)Background: <br>Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed an antibiotic, which may not always be appropriate and may cause harm. C-reactive protein (CRP) is an acute-phase biomarker that can be rapidly measured at the point of care and may predict benefit from antibiotic treatment in AECOPD. It is not clear ... -
Guidance on C-reactive protein point-of-care testing and complementary strategies to improve antibiotic prescribing for adults with lower respiratory tract infections in primary care
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-30)The world faces the threat of increasing antimicrobial resistance, and there is growing consensus that swift action must be taken to improve the rational use of antibiotics and increase the stewardship of antibiotics to safeguard this key resource in modern healthcare. This paper provides the perspective of an international group of experts on the role of C-reactive protein point-of-care testing ... -
The Role of CRP POC Testing in the Fight against Antibiotic Overuse in European Primary Care: Recommendations from a European Expert Panel
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-15)Tackling antibiotic resistance represents one of the major challenges in modern medicine, and limiting antibiotics’ overuse represents the first step in this fight. Most antibiotics are prescribed in primary care settings, and lower respiratory tract infections (LRTIs) are one of the most common indications for their prescription. An expert panel conducted an extensive report on C-reactive protein ...
